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It is used in preference to morphine, because side effects are infrequent at the usual antitussive dose of codeine. Following oral administration, nasal decongestion may occur within or minutes and may persist for up to hours. Codeine is methylene in patients with a known hypersensitivity to the drug.

Antihistamines and codeine are both contraindicated for use in the treatment of lower respiratory tract symptoms, including asthma.

The diagnostic evaluation of patients with this syndrome is complicated. Other important considerations in the Realbutts sabrina diagnosis include central anticholinergic toxicity, heat stroke, drug fever and primary central nervous system CNS pathology.

In pediatric patients who are acutely ill associated with dehydration, there is an increased susceptibility to dystonias with the use of promethazine HCl. Drugs having anticholinergic properties should be used with caution in patients with narrow angle glaucoma, prostatic hypertrophy, stenosing peptic ulcer, pyloroduodenal obstruction, and bladder neck obstruction. Drug interactions, including an increased incidence of extrapyramidal effects, have been reported when some MAOI and phenothiazines are used concomitantly. Phenylephrine with prior administration of monoamine oxidase inhibitors MAOI.

There are no studies in humans, and the significance of these findings to humans, if any, is not known. Hyperexcitability and abnormal movements have been reported in patients following a single administration of promethazine HCI. A paradoxical reaction has been reported in children receiving single doses of mg to mg orally, characterized by hyperexcitability and nightmares.

Dextromethorphan hydrobromide is a salt of the methyl ether of the dextrorotatory isomer of levorphanol, a narcotic analgesic. And untreated or inadequately treated extrapyramidal signs and symptoms EPS. Administration of promethazine has been associated with reported cholestatic jaundice.

Dextromethorphan should be used with caution in sedated patients, in the debilitated, and in patients confined to the supine position. Drug interactions, including an increased incidence of extrapyramidal effects, have been reported when some MAOI and phenothiazines are used concomitantly. Diagnostic pregnancy tests based on immunological reactions between HCG and anti HCG may result in false negative or false positive interpretations. Although antihistamines have been found to produce fetal mortality in rodents, the pharmacological effects of histamine in the rodent do not parallel those in man.

Consideration should be given to the discontinuation of promethazine HCl and to the use of other drugs if these reactions occur. Each teaspoon mL of Levodopa er HCl Syrup Plain contains.

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